My Neighbors Wife is about two couples who are best friends and the emotional ups and downs that people go through when faced with marital infidelity. In a nutshell, conflict ensues when Carla Abellana decides to break up with her husband Jake Cuenca because of Jake’s one night stand mistake with Lovi Poe, a mistake that also rips apart Lovi’s marriage with Dennis Trillo. The movie tackles what happens when couples break up— what happens to their friendship, what happens to their perspective on relationships, and how it changes the way they view their own.